hydroxyl radical

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (2) Cytochrome P450 (1) Ferroptosis (1) Fluorescent Dye (5) Reactive Oxygen Species (8)
By Research Areas:	Cancer (7) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121137

BMPO BocMPO	Others	Others
BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals .

HY-135152

CYPMPO	Reactive Oxygen Species	Cancer
CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity .

HY-N9095

Curculigoside C	Others	Neurological Disease
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC₅₀ values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively .

HY-N0948

Rhododendrol (R)-(-)-Rhododendrol; (-)-Betuligenol	Others	Inflammation/Immunology
Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla .

HY-D0113

7-Hydroxy-4-methyl-2(1H)-quinolone	Reactive Oxygen Species	Others
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .

HY-100592

Nicaraven

2 Publications Verification

Others Cancer

Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.
HY-D1395

RH-EDA

Reactive Oxygen Species Others

RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.
HY-P4280

Arg-Tyr

Reactive Oxygen Species Others

Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

Nicaraven 2 Publications Verification	Others	Cancer
Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.

RH-EDA	Reactive Oxygen Species	Others
RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.

Arg-Tyr	Reactive Oxygen Species	Others
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

HY-D1159

HKOH-1r 2 Publications Verification	Reactive Oxygen Species Fluorescent Dye	Others
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-N9497

Galactinol

Biochemical Assay Reagents Others

Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .
HY-N3289

Methyl 3,4,5-trimethoxycinnamate

Others Others

Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects .

Galactinol	Biochemical Assay Reagents	Others
Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .

Methyl 3,4,5-trimethoxycinnamate	Others	Others
Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects .

HY-135258

Galactinol dihydrate	Others	Others
Galactinol dihydrate is a marker for seed longevity. Galactinol dihydrate can scavenge hydroxyl radicals and protect plant cells from oxidative damage caused by MV treatment, salinity, or chilling .

HY-D1151

HKOH-1	Reactive Oxygen Species Fluorescent Dye	Others
HKOH-1 is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-112554

PDM11	Others	Others
PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays .

HY-130025

HKOCl-3

1 Publications Verification

Fluorescent Dye Others

HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.E_x: 490 nm; E_m 527 nm .

HKOCl-3 1 Publications Verification	Fluorescent Dye	Others
HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.E_x: 490 nm; E_m 527 nm .

HY-N2627

Isorhamnetin 3-O-robinobioside	Others	Cancer
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-126241

RV01	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity . RV01 decreases iNOS expression, with anti-neuroinflammatory activity .

HY-D0261

Tiron	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

HY-111314

NZ 419 5-Hydroxy-1-methylhydantoin	Others	Inflammation/Immunology
NZ 419 (5-Hydroxy-1-methylhydantoin) is a metabolite of creatinine and an antioxidant with oral activity, which has the ability to scavenge hydroxyl radicals (•OH). NZ 419 can inhibit the progression of chronic kidney disease (CKD) in rats .

HY-N2625A

Harmalol hydrochloride	Cytochrome P450	Others
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-N0828

Pterostilbene 5 Publications Verification	Autophagy	Inflammation/Immunology Cancer
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-W027951

N,N'-Dimethylthiourea DMTU	Reactive Oxygen Species	Inflammation/Immunology
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .

HY-111330

Hydroxyphenyl Fluorescein 1 Publications Verification HPF; 3'-p-(Hydroxyphenyl) fluorescein	Fluorescent Dye Reactive Oxygen Species	Others
Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

HY-D1301

BODIPY 581/591 C11 Maximum Cited Publications 20 Publications Verification	Fluorescent Dye Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

HY-76779

4-(Chloromethyl)-7-hydroxycoumarin	Others	Cancer
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .

Cat. No.	Product Name	Type

HY-D1159

HKOH-1r 2 Publications Verification	Fluorescent Dyes/Probes
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-D1151

HKOH-1	Fluorescent Dyes/Probes
HKOH-1 is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-130025

HKOCl-3

1 Publications Verification

Fluorescent Dyes/Probes

HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.E_x: 490 nm; E_m 527 nm .

HKOCl-3 1 Publications Verification	Fluorescent Dyes/Probes
HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.E_x: 490 nm; E_m 527 nm .

HY-111330

Hydroxyphenyl Fluorescein 1 Publications Verification HPF; 3'-p-(Hydroxyphenyl) fluorescein	Fluorescent Dyes/Probes
Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

Hydroxyphenyl Fluorescein

1 Publications Verification

HPF; 3'-p-(Hydroxyphenyl) fluorescein

Fluorescent Dyes/Probes

Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

HY-D0113

7-Hydroxy-4-methyl-2(1H)-quinolone	Fluorescent Dyes/Probes
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .

HY-D1301

BODIPY 581/591 C11 Maximum Cited Publications 20 Publications Verification	Fluorescent Dyes/Probes
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

BODIPY 581/591 C11

Maximum Cited Publications

20 Publications Verification

Fluorescent Dyes/Probes

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

Cat. No.	Product Name	Type

HY-N9497

Galactinol

Biochemical Assay Reagents

Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .

Galactinol	Biochemical Assay Reagents
Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .

Cat. No.	Product Name	Target	Research Area

HY-145779

H-Glu(Met-OH)-OH

Peptides Metabolic Disease

H-Glu(Met-OH)-OH could induce oxidation of hydroxyl radical .
HY-P4280

Arg-Tyr

Reactive Oxygen Species Others

Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

H-Glu(Met-OH)-OH	Peptides	Metabolic Disease
H-Glu(Met-OH)-OH could induce oxidation of hydroxyl radical .

Arg-Tyr	Reactive Oxygen Species	Others
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2625A

Harmalol hydrochloride	Alkaloids Structural Classification Monophenols Classification of Application Fields Zygophyllaceae Source classification Peganum harmala Linn. Other Diseases Phenols Pyridine Alkaloids Plants Disease Research Fields	Cytochrome P450
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-N9095

Curculigoside C	Curculigo orchioides Gaertn. Structural Classification Source classification Phenols Polyphenols Plants Amaryllidaceae	Others
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC₅₀ values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively .

HY-N0948

Rhododendrol (R)-(-)-Rhododendrol; (-)-Betuligenol	Structural Classification Classification of Application Fields Source classification Whitening Agent Plants Monophenols Rhododendron simsii Planch. Phenols Cosmetic Research Ericaceae Inflammation/Immunology Disease Research Fields Cancer	Others
Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla .

HY-N3289

Methyl 3,4,5-trimethoxycinnamate	Structural Classification Natural Products Source classification Plants Brassicaceae Mutarda nigra (L.) Bernh.	Others
Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects .

HY-N2627

Isorhamnetin 3-O-robinobioside	Structural Classification Flavonoids Cactaceae Flavones Source classification Opuntia ficus-indica (L.) Mill. Plants	Others
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-N0828

Pterostilbene 5 Publications Verification	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-W027951

N,N'-Dimethylthiourea DMTU	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Allium sativum Linn. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .

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